Rigevidon induce menstruation. Rigevidon and menstruation - features of the menstrual cycle, application rules. Features of menstruation upon cancellation

Emotional, physical and psychological condition affects the woman's body. First of all, this is reflected in the reproductive system. Hormone deficiency and recovery menstrual cycle can be adjusted with the help of special preparations, one of which is Rigevidon.

What is it for?

Most often, this medication is used as a contraceptive, but sometimes it is also used in medicinal purposes. Taking Rigevidon throughout the year helps to normalize the menstrual cycle, reduce cramps in the lower abdomen. In addition, the use of the drug warns against the development of a number of gynecological diseases: cancer, ovarian cysts, mastopathy, breast fibrocystosis, fibroadenomas and congestive formations in the pelvis.

pharmachologic effect

Rigevidon is an oral contraceptive. The main active substances of the drug are levonorgestrel and ethinylestradiol. Hormones are distributed in tablets in the same dosage.

Monophasic oral contraceptive hormonal drug, consisting of two components - a progestogen (levonorgestrel) and an estrogen (ethinyl estradiol). Its action is carried out primarily by inhibiting ovulation by preventing the release of FSH and LH, as well as by increasing mobility. fallopian tubes and increase the viscosity of the secretion of the cervix, inhibition of egg implantation in the endometrium and difficulty in the movement of spermatozoa.
When administered orally, the components of Rigevidon are quickly and almost completely absorbed in the digestive tract. The maximum concentration of levonorgestrel in plasma is reached after 2 hours, and ethinylestradiol - after 1.5 hours. Both components are metabolized in the liver. The half-life of ethinylestradiol is 2-7 hours. 60% of levonorgestrel is excreted in the urine, 40% in the feces; 40% of ethinylestradiol is excreted in the urine, 60% in the feces. Both components pass into breast milk.

Indications for the use of the drug Rigevidon

Contraception.

The use of the drug Rigevidon

The drug is started on the 1st day of the onset of menstruation and taken 1 tablet per day for 21 days (at the same time of day, if possible - in the evening). After that, a 7-day break is taken, during which menstrual-like bleeding usually occurs. The next package containing 21 tablets should be started on the 8th day after a 7-day break (4 weeks after taking the first tablet on the same day of the week).
Taking the drug according to this scheme can be continued as long as prevention of pregnancy is required. With regular use of Rigevidon, the contraceptive effect persists for a 7-day interval.
When switching to Rigevidon from another oral contraceptive, a similar scheme is used.
After an abortion, the use of the drug should be started on the same or the next day after the operation.
After childbirth, the use of the drug should begin no earlier than the 1st day of menstruation after the first two-phase cycle. As a rule, the first biphasic cycle is shortened due to premature ovulation. If you start taking the drug already when the first spontaneous bleeding occurs, then in the first 2 weeks of the cycle, contraception may be unreliable .
If for some reason a woman missed taking a pill at a certain time, then she should take it over the next 12 hours. The contraceptive effect cannot be considered stable if more than 36 hours have passed between doses of 2 tablets. However, Rigevidon must be continued to prevent premature bleeding . In this case, it is recommended to additionally use another non-hormonal method of contraception (with the exception of methods for measuring temperature and calendar).

Contraindications to the use of the drug Rigevidon

Hypersensitivity to the components of the drug, the period of pregnancy and lactation, severe liver failure, congenital hyperbilirubinemia (Dubin-Johnson and Rotor syndromes), cholelithiasis, cholecystitis, chronic colitis; the presence or indication of a history of severe cardiovascular and cerebrovascular diseases, thromboembolism and a predisposition to them, liver tumors, malignant tumors, especially breast or endometrial cancer; lipid metabolism disorders, severe hypertension (arterial hypertension), severe diabetes mellitus, other endocrinological diseases, sickle cell anemia, chronic hemolytic anemia, vaginal bleeding of unknown etiology, migraine, otosclerosis (which was aggravated during previous pregnancies); idiopathic jaundice in pregnant women, severe pruritus in pregnant women, herpes in pregnant women in history.

Side effects of Rigevidon

The drug is usually well tolerated. At the beginning of the use of Rigevidon, in some cases, there may be digestive disorders, nausea, vomiting, swelling of the mammary glands, headache, mood changes, fatigue, skin rash, calf muscle cramps, changes in libido, intermenstrual bleeding, discomfort when using contact lenses, however, further expressiveness of these phenomena decreases or they completely disappear. Rigevidon can cause both an increase and a decrease in body weight. When taking the drug, it is necessary to take into account the possibility of impaired glucose tolerance. With longer use, chloasma may very rarely occur. Occasionally, an increase in the level of TG in the blood plasma, an increase in blood pressure, thrombosis and thromboembolism of various localization, hepatitis, gallbladder disease, jaundice, hair loss, changes in vaginal secretion, vaginal mycosis, and diarrhea are noted.

Special instructions for the use of the drug Rigevidon

Before starting the use of the drug, it is necessary to conduct a general clinical and gynecological examination (primarily measuring blood pressure, determining the level of glucose in the urine, examining liver function, examining the mammary glands, cytological analysis smears). For women with a family history of thromboembolic disease or blood clotting disorders in close relatives at a young age, the use of Rigevidon is contraindicated.
Special care is required in the presence of diabetes mellitus, heart disease of non-ischemic etiology, impaired renal function, hypertension (arterial hypertension), varicose veins, phlebitis, otosclerosis, multiple sclerosis, epilepsy and migraine, or if a history of these diseases is indicated; with small chorea, intermittent porphyria, tetany, asthma, benign tumors of the uterus, endometriosis or mastopathy.
While taking the drug, it is necessary to conduct control examinations every 6 months.
The use of the drug is allowed no earlier than 6 months after the transferred viral hepatitis subject to the normalization of liver function. With prolonged use of sex hormones, benign, very rarely, malignant liver tumors were occasionally detected. With the appearance of acute pain in the upper abdomen, hepatomegaly and signs of intra-abdominal bleeding, the presence of a liver tumor should be excluded. In this case, the drug is stopped.
In the absence of bleeding when the drug is discontinued, its use can be continued only after the exclusion of pregnancy.
In case of violation of liver function while taking the drug, it is necessary to conduct a medical examination every 2-3 months.
With the appearance of intermenstrual bleeding, Rigevidon should be continued, since in most cases these bleedings stop spontaneously. If intermenstrual bleeding does not disappear or recurs, it is necessary to conduct a gynecological examination to exclude gynecological pathology.
In the event of vomiting, diarrhea, the drug should be continued, however, it is necessary to use an additional method of contraception.
In women who have used oral contraceptives containing estrogens, the likelihood of developing thromboembolism and thrombosis of various localization may increase. This risk increases with age and mainly in female smokers. Therefore, women over the age of 30 are advised to completely stop smoking.
The drug should be stopped at least 3 months before the planned pregnancy, and immediately stopped if pregnancy is suspected, if a migraine-like headache occurs, a significant deterioration in visual acuity, if thrombosis or heart attack is suspected, with a sharp increase in blood pressure, jaundice or hepatitis without jaundice, with severe pruritus, epilepsy, 6 weeks before a planned operation, with prolonged immobilization.

Interactions of the drug Rigevidon

Rigevidone should be used with caution in combination with ampicillin, rifampicin, chloramphenicol, neomycin, phenoxymethylpenicillin, sulfonamides, tetracyclines, dihydroergotamine, tranquilizers, phenylbutazone (these drugs may reduce the contraceptive effect, therefore it is recommended to use another non-hormonal method of contraception), with anticoagulants, coumarin derivatives or indinedione (it may be necessary to determine the prothrombin time and adjust the dose of the anticoagulant), tricyclic antidepressants, maprotiline, β-adrenergic receptor blockers (bioavailability and toxicity may increase), with oral hypoglycemic drugs, insulin (there may be a need to adjust the dose), bromocriptine (decrease efficiency), hepatotoxic drugs, especially with dantrolene (risk of increased hepatotoxicity, especially in women over the age of 35 years).

Rigevidon overdose, symptoms and treatment

Severe headache, dyspeptic disorders (nausea), vaginal bleeding due to drug withdrawal are possible. There is no specific antidote. The drug is canceled, symptomatic treatment is carried out.

Storage conditions of the drug Rigevidon

At a temperature of 15-30 °C.

List of pharmacies where you can buy Rigevidon:

• St. Petersburg

P N012676/02

Tradename:

RIGEVIDON ®

International non-proprietary name or grouping name:

Ethinylestradiol + Levonorgestrel

Dosage form:

coated tablets

COMPOUND

Active substances:
Ethinylestradiol: 0.03 mg
Levonorgestrel; 0.15 mg
Excipients:
- in the tablet core: colloidal silicon dioxide, magnesium stearate, talc, corn starch, lactose monohydrate;
- in a tablet shell: sucrose, talc, calcium carbonate, titanium dioxide, copovidone, macrogol 6000, colloidal silicon dioxide, povidone, carmellose sodium.

Description

White, round, biconvex film-coated tablets.

Pharmacotherapeutic group:

contraceptive (estrogen + gestagen)

ATC code: G03AA07.

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

Rigevidon is an oral monophasic combined estrogen-progestin contraceptive drug.
When taken orally, it inhibits the pituitary secretion of gonadotropic hormones.
The contraceptive effect is associated with several mechanisms. As a progestogen component (progestin), it contains a derivative of 19-nortestosterone - levonorgestrel, which is superior in activity to the hormone of the corpus luteum progesterone (and the synthetic analogue of the latter - pregnin), acts at the receptor level without prior metabolic transformations. The estrogenic component is ethinylestradiol. Under the influence of levonorgestrel, a blockade of the release of releasing hormones (LH and FSH) of the hypothalamus occurs, inhibition of the secretion of gonadotropic hormones by the pituitary gland, which leads to inhibition of the maturation and release of an egg ready for fertilization (ovulation). The contraceptive effect is enhanced by ethinyl estradiol. Maintains high viscosity of cervical mucus (makes it difficult for spermatozoa to enter the uterine cavity). Along with the contraceptive effect, when taken regularly, it normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, incl. tumor nature.

Pharmacokinetics

Levonorgestrel is rapidly absorbed (less than 4 hours). Levonorgestrel does not have a first pass effect through the liver. With the combined use of levonorgestrel with ethinyl estradiol, there is a relationship between dose and maximum plasma concentration. TC max (time to reach maximum concentration) of levonorgestrel is 2 hours, T 1/2 (half-life) - 8-30 hours. (average 16 hours). Most of Levonorgestrel binds in the blood to albumin and SHBG (Sex Hormone Binding Globulin).
Ethinylestradiol rapidly and almost completely absorbed from the intestine. Ethinyl estradiol is characterized by the effect of the primary passage through the liver, TC max is 1.5 hours, the half-life is about 26 hours.
When administered orally, ethinylestradiol is excreted from the blood plasma within 12 hours, the elimination half-life is 5.8 hours.
The metabolism of ethinylestradiol is carried out in the liver and intestines. Ethinyl estradiol metabolites are water-soluble products of sulfate or glucuronide conjugation, enter the intestine with bile, where they are disintegrated by intestinal bacteria.
Both components (levonorgestrel and ethinylestradiol) are excreted with breast milk. Active substances are metabolized in the liver, T 1/2 is 2-7 hours.
excretion of levonorgestrel is carried out by the kidneys (60%) and through the intestines (40%); ethinylestradiol - by the kidneys (40%) and through the intestines (60%).

INDICATIONS FOR USE

Oral contraception, functional menstrual disorders (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia, premenstrual syndrome).

CONTRAINDICATIONS

Hypersensitivity to the components of the drug, pregnancy, lactation, severe liver disease, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), cholecystitis, the presence or history of severe cardiovascular and cerebrovascular changes, thromboembolism and predisposition to them , liver tumors, malignant tumors, especially breast or endometrial cancer; familial forms of hyperlipidemia, severe forms of arterial hypertension, severe forms of diabetes mellitus and other diseases of the endocrine glands, sickle cell anemia, chronic hemolytic anemia, hydatidiform drift, age over 40 years, vaginal bleeding of unknown etiology, migraine, otosclerosis; history of idiopathic jaundice of pregnant women, severe pruritus of pregnant women, herpes of pregnant women.

CAREFULLY

Diseases of the liver and gallbladder, epilepsy, depression, ulcerative colitis, uterine fibroids, mastopathy, tuberculosis, kidney disease, adolescence(without regular ovulatory cycles).
In the presence of diabetes mellitus, diseases of the cardiovascular system, arterial hypertension, impaired renal function, varicose veins veins, phlebitis, otosclerosis, multiple sclerosis, epilepsy, chorea minor, intermittent porphyria, latent tetany, bronchial asthma prescribing the drug also requires caution.

PREGNANCY AND LACTATION

During pregnancy and lactation, the drug is contraindicated.

METHOD OF APPLICATION AND DOSES

Apply inside, without chewing and drinking a small amount of liquid.
If during the previous menstrual cycle hormonal contraception was not carried out, contraception with Rigevidon is started from the first day of menstruation, taking 1 tablet daily for 21 days, at the same time of day.
This is followed by a 7-day break, during which menstrual-like bleeding occurs. The next 21-day cycle of taking tablets from a new package containing 21 tablets must be started the day after the 7-day break, i.e. on the eighth day, even if the bleeding has not stopped. Thus, the start of taking the drug from each new package falls on the same day of the week.
When switching to taking Rigevidon from another oral contraceptive a similar scheme applies. The drug is taken for as long as there is a need for contraception.
After an abortion, it is recommended to start taking the drug on the day of the abortion or the day after the operation.
After childbirth, the drug can be prescribed only to women who are not breastfeeding; you should start taking contraceptives no earlier than the first day of menstruation. During lactation, the use of the drug is contraindicated.
missed pills; the missed tablet should be taken within the next 12 hours. If 36 hours have passed since the last pill, contraception is unreliable. In order to avoid intermenstrual bleeding, the drug should be continued from the already started package, with the exception of the missed tablet(s). In cases of skipping pills, it is recommended to additionally use another, non-hormonal method of contraception (eg, barrier).
For medicinal purposes; the dose of Rigevidon and the scheme of application are selected by the doctor in each case individually.

SIDE EFFECT

The drug is usually well tolerated.
Possible side effects transient nature, spontaneously passing: nausea, vomiting, headache, breast engorgement, changes in body weight and libido, mood changes, acyclic spotting, in some cases - swelling of the eyelids, conjunctivitis, blurred vision, discomfort when wearing contact lenses (these phenomena are temporary and disappear after cancellation without prescribing any therapy).
With prolonged use, chloasma, hearing loss, generalized itching, jaundice, cramps of the calf muscles, and an increase in the frequency of epileptic seizures can very rarely occur. Rarely observed hypertriglyceridemia, hyperglycemia, decreased glucose tolerance, increased blood pressure(AD), thrombosis and venous thromboembolism, jaundice, skin rashes, changes in the nature of vaginal secretion, vaginal candidiasis, fatigue, diarrhea.

OVERDOSE

Cases of development of toxic effects due to overdose are unknown.

INTERACTION WITH OTHER DRUGS

Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives can increase the metabolism of the steroid hormones that make up the drug.
A decrease in contraceptive efficacy can also be observed with simultaneous administration with certain antimicrobial drugs (ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with a change in the microflora in the intestine.
When using anticoagulants, coumarin or indandione derivatives, it may be necessary to additionally determine the prothrombin index and change the dose of the anticoagulant.
When using tricyclic antidepressants, maprotiline, beta-blockers, their bioavailability and toxicity may increase.
When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose.
When combined with bromocriptine, the effectiveness of bromocriptine is reduced.
When combined with drugs with a potential hepatotoxic effect, for example, with the drug dantrolene, an increase in hepatotoxicity is observed, especially in women over 35 years of age.

SPECIAL INSTRUCTIONS

Before starting contraception and, thereafter, every 6 months. a general medical and gynecological examination is recommended, including a cytological analysis of a smear from the cervix, an assessment of the condition of the mammary glands, determination of blood glucose, cholesterol and other indicators of liver function, blood pressure control, urinalysis).
The appointment of Rigevidon to women with thromboembolic diseases at a young age and an increase in blood clotting in a family history is not recommended.
The use of oral contraception is allowed no earlier than 6 months after viral hepatitis, subject to the normalization of hepatic functions.
With the appearance of sharp pains in the upper abdomen, hepatomegaly and signs of intra-abdominal bleeding, a liver tumor may be suspected. If necessary, the drug should be discontinued.
In case of deterioration of hepatic functions while taking Rigevidon, it is necessary to consult a therapist.
With the appearance of acyclic (intermenstrual) bleeding, Rigevidon should be continued, since in most cases these bleedings stop spontaneously. If acyclic (intermenstrual) bleeding does not disappear or recurs, a medical examination should be carried out to rule out organic pathology of the reproductive system.
In case of vomiting or diarrhea, the drug should be continued, additionally using another, non-hormonal method of contraception.
Smoking women taking hormonal contraceptives, have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and with the number of cigarettes smoked (especially in women over 35).
The drug should be discontinued in the following cases:
- when a migraine-like headache appears for the first time or increases, or an unusually severe headache appears;
- with the appearance of early signs of phlebitis or phlebothrombosis (unaccustomed pain or swelling of the veins in the legs);
- in case of jaundice or hepatitis without jaundice;
- with cerebrovascular disorders;
- with the appearance of stabbing pains of unclear etiology when breathing or coughing, pain and a feeling of tightness in the chest;
- with acute deterioration of visual acuity;
- in case of suspected thrombosis or infarction;
- with a sharp increase in blood pressure;
- in case of generalized itching;
- with an increase in epileptic seizures;
- 3 months before the planned pregnancy, approximately 6 weeks before the planned surgical intervention, with prolonged immobilization.
- in the presence of pregnancy.

EFFECT OF THE DRUG ON THE ABILITY TO DRIVE A CAR AND OTHER MECHANISMS
Taking the drug does not affect the ability to drive a car and other mechanisms, work with which is associated with an increased risk of injury.

RELEASE FORM

Tablets;
21 tablets in a blister made of PVC / PVDC film and aluminum foil;
1 or 3 blisters in a cardboard box with instructions for use.

STORAGE CONDITIONS

At a temperature of 15-30 °C.
Keep the drug in a place inaccessible to children!

BEST BEFORE DATE

5 years. Do not use after the expiration date.

TERMS AND CONDITIONS OF DISCOUNT FROM PHARMACIES

On prescription.

MANUFACTURER

OJSC "Gedeon Richter",
1103 Budapest, st. Demrei, 19-21, Hungary.
Consumer claims should be sent to:
Moscow Representative Office of JSC "Gedeon Richter"

Rigevidon is a contraceptive pill that contains a low dose of hormones and can be used as a method of contraception and the treatment of certain gynecological diseases.

WARNING: The drug has contraindications. Do not start using this drug without first talking to your doctor.

The composition of the tablets and packaging

Rigevidon belongs to the group of monophasic contraceptive pills. This means that all tablets in a package contain the same dose of hormones. One tablet of Rigevidon contains 30 micrograms of ethinylestradiol and 150 micrograms of levonorgestrel. One blister (plate) of Rigevidon contains 21 tablets, designed for 21 days of administration.

Rigevidon 21+7 contains 28 tablets in one blister (plate). White tablets have the same dosage of hormones as regular Rigevidon (30 micrograms of ethinyl estradiol and 150 micrograms of levonorgestrel), and reddish-brown tablets do not contain hormones, being essentially placebo pills, or dummies.

Benefits of Rigevidon

Birth control pills Rigevidon has a reliable contraceptive effect, and, if taken correctly, provides high protection against unwanted pregnancy. The contraceptive effect of Rigevidon is carried out by temporarily suppressing ovulation in the ovaries and increasing the viscosity of mucus in the cervical canal.

Taking Rigevidon for 3 consecutive months or more helps to normalize the menstrual cycle, reduce and reduce blood loss during menstruation. Against the background of taking OK Rigevidon, the risk of developing mastopathy, ovarian cancer, uterine cancer and some other gynecological diseases is reduced.

The effect of the drug is reversible. Already in the first months after stopping Rigevidon, a woman becomes fertile again.

Rules for taking Rigevidon

Rigevidon is recommended to take one tablet per day, at any convenient time of the day, regardless of food intake. If you are concerned about the side effects of the drug (nausea, headache), then it is recommended to move the time of taking the tablets to the evening.

If you have not used any hormonal contraceptives in the past month

It is recommended to start taking Rigevidon on the first day of the menstrual cycle (on the first day of menstruation). After you start taking the pills, your periods may become more scanty, or they may stop altogether. This is normal. It is also possible that menstruation will not stop, but on the contrary, will drag on for 7-10 days or more. This is also normal.

Drink Rigevidon one tablet a day for 21 days in a row. After the tablets in the blister are over, take a 7-day break. In the 7-day break, you may start your period. Regardless of whether menstruation has ended, always start a new pack of Rigevidon on the 8th day after a week break.

If you are taking Rigevidon 21+7, then start taking the drug with white tablets and take one white tablet for 21 days. After the white pills are over, start taking the reddish-brown pills. You may have your period while taking the last seven tablets. Despite menstruation, continue to take the pills every day. After the end of the blister (taking the last reddish-brown tablet), start a new pack the next day, without interruption.

When will the contraceptive effect come?

The contraceptive effect of Rigevidon occurs immediately if you start taking pills on the first day of your period. In this case, you may not use additional methods of protection against pregnancy.

If you took the first pill of Rigevidon from the 2nd to the 5th day of your period, then you need to use another 7 days after you start taking the pills. The contraceptive effect will come after taking the eighth pill.

Will the contraceptive effect last in a week break?

If in the previous month you took the pills correctly (without gaps and without factors that reduce the effect of OK), then the contraceptive effect of Rigevidon remains between packs, and you do not need to use additional methods of contraception.

If you have had gaps, or the effect of the tablets could be reduced for other reasons (diarrhea, vomiting, drinking large doses of alcohol, taking medication), see the instructions in the relevant paragraphs.

How to switch to Rigevidon from other birth control pills?

If previous birth control pills contained 21 pills in a blister pack:

you can start taking Rigevidon the next day after the last tablet of the previous OK, or

on the eighth day after the end of the previous OK

If previous birth control pills contained 28 pills in a blister pack:

you can start taking Rigevidon the next day after the last active pill, or

the day after 28 tablets of the previous OK

If you did not have time to start taking Rigevidon within the specified time, then you should wait for the next menstruation and drink the first pill on the first day of menstruation. In order to avoid unwanted pregnancy, other methods of contraception should be used before taking the pills.

How to switch to Rigevidon from a vaginal ring or from a hormonal patch?

When switching to Rigevidon from the vaginal ring, the first tablet should be taken on the day the ring was removed, or on the day when a new ring had to be installed.

When switching to Rigevidon from the first tablet of the drug, you need to drink it on the day the patch is removed, or on the day when you would need to put a new patch.

How to switch to Rigevidon from an intrauterine device (IUD)?

Take the first tablet of Rigevidon on the day of removal of the intrauterine device. The contraceptive effect will come only after 7 days of taking Rigevidon, so use condoms or other methods of contraception up to the eighth tablet.

If you did not have time to start taking Rigevidon on time, then wait for the next menstruation and take the first tablet of the drug on the first day of menstruation. Before you start taking Rigevidon, use other methods of protection against pregnancy.

What should I do if I mixed up the order of taking Rigevidon?

If your pack of Rigevidon contains 21 tablets, then nothing bad will happen. All pills in the package have the same dose of hormones, so the body will not "notice" the difference. Continue to drink Rigevidon further as usual: one tablet per day until the end of the package.

If you are taking Rigevidon 21 + 7 (that is, Rigevidon contains 28 tablets in a package), then pay attention to which tablets you mixed up. If instead of one white pill you took another white pill, then nothing terrible will happen, since all white pills contain the same dose of hormones. If instead of a white pill you accidentally took a reddish-brown pill, then the contraceptive effect of Rigevidon may be reduced. In this case, you need to do the same as when skipping a pill (depending on its number).

What should I do if I miss a pill of Rigevidon?

If you forgot to take another pill of Rigevidon, count how many hours have passed since you took the last pill you took. If less than 36 hours have passed since taking the last pill, the contraceptive effect of the pills will not decrease. Take the missed tablet as soon as possible and continue taking the tablets as usual.

If more than 36 hours have passed since taking the last pill, the contraceptive effect of the pills may decrease. In this case, your next steps depend on the number of the missed tablet:

1 to 7 tablets (first week of use) : Take the missed tablet as soon as possible, even if you have to take two tablets at the same time. Another 7 days after the pass, the contraceptive effect of the pills will be reduced, so in case of sexual intercourse, use other methods of contraception.

8 to 14 tablets (second week of use) : Take the missed tablet as soon as possible, even if you have to take 2 tablets at once. The contraceptive effect of the pills will not decrease if you took the pills according to the rules in the previous 7 days before the miss. That is, if you have not skipped in the last week, then you do not need to use condoms or other additional methods of contraception. If you skipped in the last week, then you need to use additional contraception within 7 days after the skip.

15 to 21 tablets (third week of use) : take the missed pill of Rigevidon as soon as you remember the pass, even if you have to take two pills at the same time. Then continue to drink the tablets as usual until the end of the package. To prevent the contraceptive effect of the pills from decreasing and you do not have an unwanted pregnancy, you should skip the 7-day break. This means that after the end of the package, you need to start the next package of Rigevidon the next day (without a break).

You do not need to use additional contraceptives if you did not have other passes in the previous 7 days before the pass. If you have skipped in the last week, then you should use condoms for 7 more days after skipping.

Rigevidon 21+7

If your package of Rigevidon contains 28 tablets, then the instructions remain the same for the first and second weeks of administration (see above). The changes relate to the third week of taking the tablets:

15 to 21 tablets: take the missed pill of Rigevidon as soon as you remember the pass, even if you have to take two pills at the same time. Then continue to drink tablets as usual up to 21 tablets (until the last white tablet). Then discard the remaining red-brown tablets and start taking a new package the day after taking the last 21 tablets. You do not need to use additional contraceptives if you did not have other passes in the previous 7 days before the pass. If you have skipped in the last week, then you should use condoms for 7 more days after skipping.

22 to 28 tablets: these are inactive pills, so skipping them will not reduce the contraceptive effect. Throw away the missed tablet and continue to take the tablets as usual.

What should I do if I missed a few pills of Rigevidon?

When skipping two Rigevidon tablets in a row contraceptive effect may be reduced. To avoid unwanted pregnancy, you should follow the instructions.

Pay attention to the numbers of missed pills. If these are tablets of the first or second week of taking (from 1 to 14), then take 2 tablets as soon as you remembered the pass and 2 more tablets the next day. Then take one tablet of Rigevidon per day until the end of the package. Use 7 more days after skipping.

If the missed pills are from the third week of taking (from 15 to 21), then you should discard the current pack of pills and start taking a new pack with the first active (white) pill. A new package should be drunk to the end and only then take a 7-day break. If you did not have any other missed days in the previous 7 days before the pass, then you do not need to use condoms or other additional methods of contraception.

When skipping 3 tablets of Rigevidon in a row, discard the current pack of pills and start a new pack with the first active (white) pill. For another 7 days, use additional contraception. If you had unprotected intercourse at the time of the pass or shortly before the pass, then the risk of pregnancy will be increased. In this case, you should do it 3.5 weeks after the last unprotected intercourse, or take it 11 days after the last unprotected intercourse.

If you are not sure what to do in your situation, use additional contraceptives (for example,) until you consult a gynecologist.

What should I do if spotting or menstruation occurs while taking Rigevidon?

While taking the drug Rigevidon or Rigevidon 21+7, you may experience spotting of varying degrees of profusion (scanty spotting or discharge similar to menstruation).

Especially often spotting appears in the first 3 months of taking Rigevidon. As a rule, this is not dangerous, does not indicate pregnancy and does not require urgent medical attention.

Despite these discharges, continue taking the tablets as usual. Do not stop taking the tablets on your own without consulting your doctor, as this may increase bleeding.

If you haven't had any missed pills, then the contraceptive effect is maintained despite these discharges, so you can continue to have sex without fear of becoming pregnant.

If bleeding occurs as a result of missing one or more tablets, continue taking Rigevidon despite these discharges. Use additional contraceptives, as the contraceptive effect of Rigevidon could be reduced as a result of skipping pills.

How to postpone menstruation with Rigevidon?

You can delay unwanted menstruation with Rigevidon tablets.

To postpone your period, drink the current package of Rigevidon to the end and then, without taking a break, start a new package the next day. The second package must be drunk to the end and only then take a break.

Due to skipping the 7-day break, you may experience spotting in the middle of the second pack. It is not dangerous and does not require urgent medical attention. Despite these discharges, continue taking the tablets as usual until the end of the package.

Rigevidon 21+7

If your package contains 28 tablets, then in order to delay unwanted menstruation, you should finish the active white tablets (up to 21 tablets inclusive) and then discard the remaining red-brown (inactive) tablets. Start a new pack the day after taking your last active tablet. The second package must be drunk to the end (including inactive tablets).

What to do if menstruation did not come during the break of Rigevidon?

While taking Rigevidon tablets, menstruation may not come in a 7-day break. As a rule, this is not dangerous, but requires increased attention from you.

If you had passes last month, or had other possible reasons reduce the contraceptive effect (diarrhea, vomiting, alcohol or medication), then you should do and consult a gynecologist. Until pregnancy is ruled out, you should not start taking a new pack of Rigevidon.

What to do if pregnancy occurs while taking Rigevidon?

The drug Rigevidon provides a high degree of protection against unwanted pregnancy, but this protection cannot be considered one hundred percent. Within one year of taking Rigevidon tablets, one woman out of 2000 becomes pregnant.

As a rule, pregnancy is the result of missing pills, or exposure to other factors that reduce the contraceptive effect (see next paragraph). However, pregnancy can occur even if the pills are taken perfectly.

If you become pregnant while taking Rigevidon, stop taking the pills immediately and contact your gynecologist. Since this drug does not cause malformations in the embryo, pregnancy can be continued despite the fact of taking birth control pills.

In what cases can the effect of Rigevidon decrease?

The effectiveness of contraception may be reduced in the following cases:

• If one or more tablets are missed
• As a result
• When used
• When (certain antibiotics, phenobarbital, epilepsy drugs, drugs, St. John's wort, etc.)

What to do if the effect of Rigevidon could be lowered?

If you suspect that the contraceptive effect of Rigevidon could be reduced, use additional contraceptives (for example, condoms) within the next 7 days.

Do I need to take long breaks while taking Rigevidon?

Some women try to take long breaks in taking Rigevidon to give the body a break from the pills. You can read about whether this is really good for the body by clicking on the link:

How to stop taking Rigevidon?

If the need for contraception has disappeared, or if you are planning a pregnancy, you should stop taking Rigevidon birth control pills.

To avoid the side effects of withdrawal and get your own menstrual cycle back on track as quickly as possible, heed the following advice from gynecologists:

Never stop taking your pills in the middle of a pack. Even if you decide to get pregnant as soon as possible, drink the current package to the end and only then stop taking the pills.

Having finished the current package of tablets to the end, just do not start a new package.

Please note that after taking the last tablet of Rigevidon, the contraceptive effect of the tablets disappears. That is, you can become pregnant in the first 7 days after stopping the pills. If you are not yet planning a pregnancy, start using other methods of contraception as soon as you stop taking the pills.

How to get pregnant after taking Rigevidon?

If you want to get pregnant, start taking at least 1 month (and even better 3 months) before planning your pregnancy.

Please note that pregnancy can occur as early as the first month after the abolition of Rigevidon tablets. However, gynecologists recommend that you start trying to conceive no earlier than 3 months after stopping the pills.

In this article, you can read the instructions for using a contraceptive drug Rigevidon. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Rigevidon in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Rigevidon in the presence of existing structural analogues. Use for the treatment of menstrual irregularities and contraception in women, including during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Rigevidon- combined monophasic oral hormonal contraceptive drug. When taken orally, it inhibits the pituitary secretion of gonadotropic hormones. The contraceptive effect is associated with several mechanisms. As a progestogen component (progestin), it contains a derivative of 19-nortestosterone - levonorgestrel, which is superior in activity to the hormone of the corpus luteum progesterone (and the synthetic analogue of the latter - pregnin), acts at the receptor level without prior metabolic transformations. The estrogenic component is ethinylestradiol.

Under the influence of levonorgestrel, a blockade of the release of LH and FSH from the hypothalamus occurs, inhibition of the secretion of gonadotropic hormones by the pituitary gland, which leads to inhibition of the maturation and release of an egg ready for fertilization (ovulation). The contraceptive effect is enhanced by ethinyl estradiol. Maintains high viscosity of cervical mucus (makes it difficult for spermatozoa to enter the uterine cavity). Along with the contraceptive effect, when taken regularly, it normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, incl. tumor nature.

Compound

Ethinylestradiol + Levonorgestrel + excipients.

Ethinylestradiol + Levonorgestrel + Iron fumarate + excipients (Rigevidon 21+7).

Pharmacokinetics

Levonorgestrel

After oral administration, levonorgestrel is rapidly absorbed (less than 4 hours). Levonorgestrel does not undergo a "first pass" effect through the liver. Most of levonorgestrel binds in the blood to albumin and SHBG (sex hormone-binding globulin).

Ethinylestradiol

Ethinylestradiol is rapidly and almost completely absorbed from the intestine. Ethinylestradiol undergoes a "first pass" effect through the liver. When ingested, ethinylestradiol is excreted from the blood plasma within 12 hours. Ethinylestradiol is metabolized in the liver and intestines. Ethinyl estradiol metabolites are water-soluble products of sulfate or glucuronide conjugation, enter the intestine with bile, where they are disintegrated by intestinal bacteria.

Indications

• oral contraception;
• functional disorders of the menstrual cycle (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia);
• premenstrual tension syndrome.

Release form

Coated tablets.

Coated tablets of two types: active and placebo (Rigevidon 21+7).

Instructions for use and regimen

The drug is taken orally at the same time of day, without chewing and with a small amount of liquid.

If during the previous menstrual cycle hormonal contraception was not carried out, then Rigevidon for the purpose of contraception is prescribed from the 1st day of menstruation, 1 tablet daily for 21 days. This is followed by a 7-day break, during which menstrual-like bleeding occurs. The next 21-day cycle of taking tablets from a new package containing 21 tablets must be started the day after the 7-day break, i.e. on the 8th day, even if the bleeding has not stopped. Thus, the start of taking the drug from each new package falls on the same day of the week.

When switching to taking Rigevidon from another oral contraceptive, a similar scheme is used. The drug is taken for as long as there is a need for contraception.

After childbirth, the drug can be prescribed only to women who are not breastfeeding; you should start taking a contraceptive no earlier than the 1st day of menstruation. During lactation, the use of the drug is contraindicated.

The missed pill should be taken within the next 12 hours. If 36 hours have passed since the last pill was taken, then contraception is unreliable. To avoid intermenstrual bleeding, the drug should be continued from the already started package, with the exception of the missed tablet(s). In cases of missed tablets, it is recommended to additionally use another, non-hormonal method of contraception (for example, a barrier).

For therapeutic purposes, the doctor sets the dose of Rigevidon and the scheme of application in each case individually.

Rigevidon 21+7

If a woman in the previous cycle took a contraceptive, the drug is started on the 1st day of the menstrual cycle and continued for 28 days. Take 1 tablet daily, preferably at the same time of day. Take the pills first white color(21 days), then while taking the reddish-brown tablets (7 days), menstrual-like bleeding usually occurs. If it is necessary to continue contraception, the next 28 tablets (21 white tablets, then 7 reddish-brown tablets) should be taken immediately without interruption according to the same scheme. Thus, each intake cycle starts on the same day of the week. In the event that a woman took a contraceptive in the previous cycle, and there were 21 tablets in the previous package, the drug should be started after a 7-day break, on the eighth day.

The composition of the tablets different color unequal. Therefore, the beginning and the correct sequence of reception - first 21 white pill, then 7 reddish-brown tablets - indicated on the package by numbers and arrows.

When switching to Rigevidon 21 + 7 from another contraceptive, you should use the above scheme.

Taking the drug after childbirth or after an abortion can be started as soon as before the first days of menstruation of the first biphasic cycle. The first biphasic cycle is usually shortened due to premature ovulation. If the drug is started already at the first spontaneous bleeding, the drug cannot successfully prevent premature ovulation, so contraception may not be reliable in the first two weeks of the cycle.

If the pill was missed at the scheduled time, then the missed pill should be taken within the next 12 hours. In this case, there is no need to use additional methods of contraception. The remaining tablets are recommended to be taken at the usual time. If more than 12 hours have passed, you should take the last missed tablet (missing the remaining missed tablets) and continue taking the drug as normal. In this case, additional methods of contraception (barrier methods, spermicides) must be used for the next 7 days.

This does not apply to reddish-brown tablets, because. they do not contain hormones.

For therapeutic purposes, the dose of the drug and the scheme of application are selected by the doctor for each patient individually.

Side effect

• nausea, vomiting;
• headache;
• engorgement of the mammary glands;
• changes in body weight and libido;
• mood change;
• acyclic spotting;
• swelling of the eyelids;
• conjunctivitis;
• visual impairment;
• discomfort when wearing contact lenses (these phenomena are temporary and disappear after withdrawal without prescribing any therapy);
• chloasma;
• hearing loss;
• generalized itching;
• cramps of the calf muscles;
• increased frequency of epileptic seizures;
• increase in blood pressure;
• thrombosis and venous thromboembolism;
• skin rashes;
• change in the nature of vaginal secretion;
• candidiasis;
• fatigue;
• diarrhea.

Contraindications

• severe liver disease;
• congenital hyperbilirubinemia (Gilbert's syndrome, Dubin-Johnson syndrome, Rotor's syndrome);
• cholecystitis;
• presence or history of severe cardiovascular and cerebrovascular diseases;
• thromboembolism and predisposition to them;
• malignant tumors (primarily breast or endometrial cancer);
• liver tumors;
• familial forms of hyperlipidemia;
• severe forms of arterial hypertension;
• endocrine diseases (including severe forms of diabetes);
• sickle cell anemia;
• chronic hemolytic anemia;
• vaginal bleeding of unknown etiology;
• cystic skid;
• migraine;
• otosclerosis;
• idiopathic jaundice of pregnant women in history;
• severe itching during pregnancy;
• herpes of pregnant women;
• age over 40;
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breastfeeding).

special instructions

Before starting the use of hormonal contraception and subsequently every 6 months, a general medical and gynecological examination is recommended, including a cytological analysis of a smear from the cervix, an assessment of the condition of the mammary glands, determination of blood glucose, cholesterol and other indicators of liver function, blood pressure control, urinalysis.

The appointment of Rigevidon for women with thromboembolic diseases at a young age and an increase in blood coagulation in a family history is not recommended.

The use of oral contraception is allowed no earlier than 6 months after viral hepatitis, subject to the normalization of hepatic functions.

With the appearance of sharp pains in the upper abdomen, hepatomegaly and signs of intra-abdominal bleeding, a liver tumor may be suspected. If necessary, the drug should be discontinued.

If there is a violation of liver function while taking Rigevidon, a consultation with a therapist is necessary.

With the appearance of acyclic (intermenstrual) bleeding, Rigevidon should be continued, because. in most cases, these bleedings stop spontaneously. If acyclic (intermenstrual) bleeding does not disappear or recurs, a medical examination should be carried out to rule out organic pathology of the reproductive system.

In case of vomiting or diarrhea, the drug should be continued using another, non-hormonal method of contraception.

Women who smoke and take hormonal contraceptives have an increased risk of developing cardiovascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and with the number of cigarettes smoked (especially in women over 35).

The drug should be discontinued in the following cases:

• when migraine-like headache appears for the first time or increases;
• with the appearance of an unusually severe headache;
• with the appearance of early signs of phlebitis or phlebothrombosis (unaccustomed pain or swelling of the veins in the legs);
• in the event of jaundice or hepatitis without jaundice;
• with cerebrovascular disorders;
• with the appearance of stabbing pains of unclear etiology when breathing or coughing, pain and a feeling of tightness in the chest;
• with acute deterioration of visual acuity;
• with suspicion of thrombosis or heart attack;
• with a sharp increase in blood pressure;
• in case of generalized itching;
• with an increase in epileptic seizures;
• 3 months before the planned pregnancy;
• approximately 6 weeks before the planned surgical intervention;
• with prolonged immobilization;
• during the onset of pregnancy.

Influence on the ability to drive vehicles and control mechanisms

Taking the drug does not affect the ability to drive Vehicle and to the control of other mechanisms, the work of which is associated with an increased risk of injury.

drug interaction

Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives can increase the metabolism of the steroid hormones that make up the drug.

A decrease in the contraceptive effectiveness of Rigevidon can also be observed when administered simultaneously with certain antimicrobial agents (including ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with changes in the intestinal microflora.

When used simultaneously with anticoagulants, coumarin or indandione derivatives, it may be necessary to additional definition prothrombin index and change in the dose of anticoagulant.

When using tricyclic antidepressants, maprotiline, beta-blockers, their bioavailability and toxicity may increase.

Alcohol intake does not lead to a decrease in the effect of the oral contraceptive Rigevidon.

When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose.

When combined with bromocriptine, its effectiveness is reduced.

When combined with drugs with a potential hepatotoxic effect, for example, with the drug dantrolene, an increase in hepatotoxicity is observed, especially in women over 35 years of age.

Rigevidon's analogues

Structural analogues for the active substance:

• Anteovin;
• Microgynon;
• minisiston;
• Minisiston 20 fem;
• Ovidon;
• Oralcon;
• Rigevidon 21+7;
• Tri-regol;
• Tri-regol 21+7;
• Trigestrel;
• Triquilar.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.