Does biltricid kill opisthorchiasis. Instructions for use of biltricide in the treatment of opisthorchiasis Contraindications and side effects

Result: positive feedback

10 +

Unpleasant but effective

Result: positive feedback

Efficacy is dose dependent

Benefits: Effective when dosed correctly

Cons: heavy side effects

Result: negative feedback

Not completely healed

Disadvantages: Did not completely get rid of worms, caused vomiting and diarrhea, undeservedly expensive

Result: positive feedback

I liked

Benefits: Heals in 2 days, effective, available for free

Disadvantages: Need preparation before treatment, may have side effects

A huge plus of Biltricid is that it cures opisthorchiasis in just two days. The biggest disadvantage of the tool is that it cannot be used without preparation and does not make sense, because there will simply be no effect. I personally did everything right - went to the infectious diseases hospital, where they gave me choleretic drugs for a week, passed the tests, and already on next week I took Biltricid - they gave it to me for free, so if you have the opportunity, go to the hospital, and you don’t need to pay for the medicine, and you will be under supervision. Although I personally didn’t need supervision - I drank all the prescribed pills, didn’t feel anything, went to bed. The next day, there were no problems either - except for a little dizziness and noise in my head, but otherwise everything was fine. After taking the pills, I spent another week in the hospital - the same choleretic and droppers. And then the reaction of the body to intoxication appeared - I was covered with acne, all the skin began to itch, my eyes constantly itched, watered and my throat was tickling. This went on for quite a long time - about a month and a half, but then everything returned to normal. Now every six months I check - so far everything is clean.

A.L. Korkin, V.V. Boars

19 healthy people and 33 patients with opisthorchiasis and cholelithiasis were examined. A comparative assessment of some indicators of cholesterol, pigment, and protein metabolism in the gallbladder and hepatic portion of bile in the examined patients before and after therapy with biltricide and ursosan was carried out. It was found that in patients with opisthorchiasis and cholelithiasis in effective terms after biltricide monotherapy, there is a significant excess of the concentration of indirect bilirubin, cholesterol and protein in gallbladder bile compared to healthy people, which indicates the preservation of residual effects with a significant improvement in pigment metabolism and a decrease in the lithogenic properties of bile. The inclusion of ursosan in the scheme of preparation and conduct of anthelmintic therapy makes it possible to achieve the greatest hypolithogenic state of the gallbladder portion of bile in an effective time period after biltricide therapy.

The chronic phase of opisthorchiasis, often asymptomatic, with normal or minimal changes in liver biochemical samples, is characterized by functional changes in the biliary system, the biochemical composition of bile in the form of a decrease in phospholipids, an increase in cholesterol and total bilirubin in the cystic and hepatic portion of bile. Some authors note a decrease in cholesterol in the cystic portion of bile. All this is considered as an increase in the lithogenic properties of bile in opisthorchiasis, increasing the risk of developing cholelithiasis.

In the light of recent ideas about lithogenesis, a drug solution to this problem is being considered as part of the development of new prevention and treatment strategies. early stages cholelithiasis.

The aim of this work was to study the level of bile lithogenic factors in patients with opisthorchiasis and cholelithiasis in effective terms after chemotherapy with biltricide and ursosan.

52 patients were examined. The first group consisted of 19 people who, according to the results of a scatological study and during duodenal sounding, did not reveal opisthorchiasis. In this group, no pathological changes in the hepatobiliary system were detected according to the results of clinical and biochemical blood tests and ultrasound of the liver, biliary system. The second group consisted of 20 patients with opisthorchiasis and stage 2 cholelithiasis. In this group, the study of the biochemical composition of bile was carried out before therapy with biltricide and 2 months after therapy with this drug. The third group (13 patients) consisted of patients with opisthorchiasis and stage 2 cholelithiasis before therapy with biltricide and ursosan and 2 months after therapy with these drugs.

In groups 2 and 3, before therapy with biltricid and ursosan, opisthorchiasis invasion was verified based on the results of scatological studies and duodenal sounding. The second stage of cholelithiasis (the stage of formation of microliths) was verified in these groups according to the results of ultrasound of the gallbladder.

Biltricid was prescribed to patients of groups 2 and 3 at the rate of 60 mg per 1 kg of the patient's weight in 3 doses during the day. Ursosan was prescribed to patients of the 3rd group 2 weeks before biltricide therapy and within 2 months after it at the rate of 10 mg per 1 kg of the patient's weight per day in 2 daily doses: in the morning and in the evening.

Determination of the level of cholesterol, bilirubin, total protein, albumin was carried out by a unified method "by the end point" on an automatic analyzer Synhron CX 5 Delta from Bekcman Culter. Protein fractions were determined by agarose gel electrophoresis on a Bekcman Culter Densitometer System Appraise electrophoretic system. Determination of alkaline phosphatase activity was carried out by an optimized kinetic method using 2-amino-2-methyl-1-propanol buffer on a Synhron CX 5 Delta automatic analyzer from Beksman Culter.

The numerical data obtained during the study are subject to statistical processing using Microsoft Excel and Stat-Soft.

In the effective terms of therapy with biltricide, there is a significant decrease in cholesterol levels in the hepatic and cystic portion of bile, which, however, exceeds the level in bile in healthy people (see Table 1).

Table 1. Indicators of cholesterol (µmol/l), cholesterol-phospholipid ratio, bilirubin, alkaline phosphatase (µmol/l), total protein and protein fractions in bile (g/l) in patients with opisthorchiasis and cholelithiasis after treatment with biltricid and ursosan (M+σ )

A decrease in the cholesterol-phospholipid ratio in the hepatic and cystic bile during the effective periods of biltricid therapy indicates a decrease in the lithogenicity of bile.

In addition, in the effective terms of therapy with biltricide in group 2, there is an improvement in the state of bilirubin metabolism in the form of a decrease in the level of total and indirect bilirubin in bile compared with the initial level (see table 1). However, the excess of the concentration of indirect bilirubin in the hepatic and gallbladder bile, even in the effective period after biltricide therapy in group 2 compared with group 1, indicates the preservation of residual changes with an improvement in pigment metabolism (p<0,05; см. таблицу 1).

When studying the indicators of protein metabolism in group 2, a significant decrease in total protein in the hepatic portion of bile was found in the effective time period after biltricide therapy compared with the baseline (see table 1).

The excess of the arithmetic mean value of γ-globulins in the hepatic and cystic bile in group 2 compared with group 1 indicates the persistence of the intensity of immunological reactions in the effective period of biltricide therapy. Although the decrease in the level of γ-globulins in bile in group 2 compared with the initial level is generally regarded as a positive trend (see table 1).

Despite the decrease in the level of albumin in gallbladder bile in group 2 during the effective period of biltricide therapy compared with the baseline, it remains quite high, exceeding the value in group 1, being an important factor in increased lithogenic activity in these patients (p<0,05; см. таблицу 1).

In effective terms after therapy with biltricid and ursosan, patients of group 3 showed the lowest values ​​of cholesterol, bilirubin and alkaline phosphatase in bile compared with patients of group 2 (see table 1). When comparing the arithmetic means of these indicators and analyzing the results of the Mann-Whitney test in groups 1 and 2, there were no statistically significant differences in the effective terms of therapy with biltricide and ursosan (p>0.05; see table 1).

When comparing the cholesterol-phospholipid ratio in the cystic and hepatic portion of bile, in the effective period after the therapy, the lowest values ​​of the indicator were noted in the group of patients of the 3rd group compared to the 2nd group.

In the study of bilirubin fractions in bile in effective terms after therapy in patients of group 3, the lowest values ​​of indirect bilirubin are noted compared with groups 1 and 2 of patients (see table 1).

The assessment of the content of total protein and its fractions in bile in effective terms after biltricide therapy in patients of the 3rd group reflects the patterns characteristic of the 2nd group. However, we found that a feature of group 3 is a lower level γ -globulins in bile in the effective terms of therapy, which does not differ statistically significantly from the level of the indicator in group 1 (p>0.05; see table 1).

Conclusions:

1. In effective terms after therapy with biltricid, a decrease in the lithogenic properties of bile was revealed, which has a significant but indirect mechanism associated with the resolution of intraductal biliary cholestasis and a decrease in inflammatory and immunological reactions in the biliary ductal system.
2. In effective terms after therapy with biltricide, a significant excess of the concentration of indirect bilirubin, cholesterol and protein in gallbladder bile compared with healthy people was revealed, which indicates the persistence of residual effects with a significant improvement in pigment metabolism and a decrease in the lithogenic properties of bile.
3. The inclusion of ursosan in the scheme of preparation and conduct of anthelmintic therapy makes it possible to achieve the greatest hypolithogenic state of the gallbladder portion of bile during the entire period after biltricide therapy and to achieve lower levels of these parameters in an effective time after deworming.
4. Ursosan has no significant effect on the intensity of inflammatory processes and the level of indirect bilirubin in bile in patients with opisthorchiasis.
5. The combined use of biltricide and ursosan makes it possible to achieve lower rates of bile lithogenicity in effective terms after biltricide therapy.

Increased eosinophilic cationic protein after taking three courses of nemozole, biltricide There were frequent recurrences of genital herpes (every month) during the year. The treatment prescribed by the venereologist did not help in any way (acyclovir 800 mg three times a day). After changing the venereologist and the hospital, an immunogram was prescribed, which showed an increased ECP value (I am attaching a photo of the analysis, the ECP analysis showed 80 ng / ml), which was in February of this year. After administration of Nemozole, the value rose to 91 ng/ml, and after subsequent courses of Nemosol and biltricide, the value gradually decreased to 36 ng/ml and remained unchanged after another course of biltricide and triad. The relapses of HH decreased (this year there were 4 times), since acyclovir was drunk for half a year. Before the first tests for ECP, anti-allergic drugs were taken, and I never observed allergies in myself, except for the fact that a runny nose begins in the cold. A few years ago I did allergy tests for the main allergens, the result was negative. What other tests need to be done to exclude or confirm the helminthic cause of an increase in ECP? You just don’t feel like drinking anthelmintic drugs, because the gastrointestinal tract is in poor condition after the courses that have already taken place.

Hello. About two years ago, my son and I were infected with opisthorchiasis. I have symptoms: mostly only allergies - itching, urticaria, my son has allergies, gastric problems, temperature. They diagnosed him by feces at the MCC NSMU. We underwent a course of treatment with biltricide in the 1st infectious diseases hospital in Novosibirsk, with preparation. Duodenal sounding after biltricide was not prescribed, but a course of 3 months was prescribed. with cholagogues and tubes of mineral water and sorbitol, all appointments were fulfilled, the symptoms disappeared. Three months later, a blood test was performed there at the MCC NGMU (on their advice), opisthorchiasis was not found. probing - opisthorchia was not detected, the symptoms were significantly weakened. I got itching mainly on the hands and feet, but less pronounced than 2 years ago. The main question is which method is the most reliable for confirming or denying opisthorchiasis: duodenal sounding or blood test for opisthorchiasis IgM / IgG / CEC, or both.? Thanks in advance.

• children's age up to 4 years;
• cysticercosis, the causative agent of which is a tapeworm;
• intolerance to individual components.

Patients in whom the heart rhythm is disturbed, take the drug under the close supervision of the attending physician. cannot be destroyed by Biltricide. Other drugs are also prescribed to combat the bovine worm.

Side effects

Praziquantel is a very strong substance that can cause side effects. Other influencing factors are some of the individual components, the degree of invasion, and the site of localization.

It is customary to highlight such side effects from taking the drug:

• malfunction of the liver leads to the development of various allergic reactions;
• nausea, vomiting;
• headache;
• heaviness in the epigastric region;
• taste of bitterness in the mouth;
• loss in space;
• temperature rise;
• insomnia.

Manifestations disappear with the abolition of the drug. Usually a person returns to the usual appearance the very next day after taking the last dose of the drug. The instructions for the use of Biltricid for opisthorchiasis indicate that treatment should be carried out only under the strict supervision of a doctor. Due to the high likelihood of side effects, a person may need urgent medical attention.

Taking the drug

General information

No one medical worker will not proceed to treatment until the patient has passed all the necessary tests. Comprehensive diagnostics includes fluorography, urine and blood tests. This will help determine the duration of the course of treatment and the intensity of rehabilitation therapy.

This rule is rather a necessity that allows you to assess the general condition of the infected. During the diagnosis, the degree of damage to internal organs and the presence of any other damage are revealed. At the time of treatment, the patient should refuse fatty foods and not drink alcohol.

Reception

The minimum age at which you can take the drug is 4 years. In this case, the dosage is set exclusively by the doctor. The drug is contraindicated for use by pregnant women and mothers during breastfeeding.

Anthelmintic therapy with Biltricid lasts no more than 3 days. In most cases, the medicine is taken three times a day, while calculating the dosage (25 mg per 1 kg of weight).

Due to the possibility of various side effects at the time of taking the drug, it is necessary to postpone any work that requires attention. During treatment, a person should be provided with maximum peace and comfort, only in this case the result will be noticeable.

Admission Information

1. You need to take the tablet in integrity without preliminary grinding.
2. The medicine is washed down exclusively with ordinary water without gas. Do not drink juice, tea, coffee or any other drinks.
3. As a rule, Biltricid is drunk during meals or before meals.
4. Usually, doctors prescribe one tablet per day. It is better to drink at night.
5. With long-term therapy and the appropriate dose, it is necessary to take breaks between doses of the drug. They should not be less than 4 hours and more than 6.

Recovery period

After treatment of opisthorchiasis, the patient is prescribed a duodenal sounding procedure. This event is necessary in order to assess the quality of treatment and exclude the further development of the disease. The procedure is repeated for two weeks.

After treatment of opisthorchiasis with Biltricid, the patient needs rehabilitation therapy. It consists in taking antispasmodics and choleretic drugs. Its duration does not exceed 1 month.

According to the condition of the infected, the doctor may prescribe additional medications if necessary. Herbal decoctions have proven themselves well. However, their reception should be long, for 2-4 months, at least. In some cases, enzymes may be prescribed.

Monitoring the effectiveness of treatment

Thus, the patient controls the state of the body and, when the helminths return, can begin a new stage of treatment. Biltricide is best for this. It instantly acts on worms, destroying them and without causing severe harm to the body.

Do not delay treatment, as lesions of internal organs can become a contraindication to the treatment of the disease.

Before starting treatment, the doctor must tell almost everything about Biltricide to every patient. Study the medical history and, after receiving all the previously passed tests, draw up a treatment regimen.

Any doctor must make sure that the drug is suitable for antihelminthic therapy and will not cause any harm to the body. Reviews about Biltricid say that if after taking the first pill there is any reaction, the medicine is canceled and they try to replace it with another one. Usually the agent is well tolerated by all patients, only in rare cases there is intolerance to individual components.

Conclusion